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Risk factors for the deterioration of glucose metabolism in polycystic ovary syndrome

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dc.contributor.authorWang, J.
dc.contributor.authorNorman, R.
dc.date.issued2004
dc.description© Reproductive Biomedicine Online
dc.description.abstractWomen with polycystic ovary syndrome (PCOS) have a high risk of abnormal glucose metabolism, which deteriorates gradually over time. This study was designed to assess contributing factors to the rate of deterioration of glucose metabolism over the 4- to 7-year follow-up period. The study group included 67 PCOS women who had normal glucose tolerance in the initial test in 1990-1992. There was a significant increase in both fasting and 2-h glucose concentrations, and body weight, over the follow-up period. The initial obesity, expressed as waist:hip ratio and BMI, was significantly related to the increase of glucose concentrations, while weight gain was not a significant factor. The overweight/obese PCOS women have a faster deterioration of glucose metabolism over the follow-up period than the non-obese ones. Moderate weight gain has no significant detrimental effect on the rate of deterioration of glucose metabolism.
dc.description.statementofresponsibilityJim Wang and Robert J. Norman
dc.identifier.citationReproductive Biomedicine Online, 2004; 9(2):201-204
dc.identifier.doi10.1016/S1472-6483(10)62130-X
dc.identifier.issn1472-6483
dc.identifier.issn1472-6491
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]
dc.identifier.urihttp://hdl.handle.net/2440/8497
dc.language.isoen
dc.publisherReproductive Healthcare Ltd.
dc.source.urihttp://www.rbmonline.com/4DCGI/Article/Detail?38%091%09=%201352
dc.subjectDiabetes
dc.subjectglucose metabolism
dc.subjectobesity
dc.subjectPCOS
dc.subjectBMI
dc.titleRisk factors for the deterioration of glucose metabolism in polycystic ovary syndrome
dc.typeJournal article
pubs.publication-statusPublished

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