Biofilm and osteitis in refractory chronic rhinosinusitis
Date
2017
Authors
Zhao, Y.
Wormald, P.
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Journal article
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Otolaryngologic Clinics of North America, 2017; 50(1):49-60
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Yi Chen Zhao and Peter-John Wormald
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Abstract
Our understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease's pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent. Surgery remains the mainstay treatment for biofilm and osteitis with mechanical disruption and removal of disease load providing the most effective treatment.
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© 2016 Elsevier Inc. All rights reserved.