Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis: the role of basic cofactors
Date
2006
Authors
Fanning, A.M.
Plush, S.E.
Gunnlaugsson, T.
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Chemical Communications, 2006; (36):3791-3793
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Abstract
The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer.
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