Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage

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dc.contributor.authorPalaniappan, R.
dc.contributor.authorSingh, S.
dc.contributor.authorSingh, U.
dc.contributor.authorSakthivel, S.
dc.contributor.authorAdes, E.
dc.contributor.authorBriles, D.
dc.contributor.authorHollingshead, S.
dc.contributor.authorPaton, J.
dc.contributor.authorSampson, J.
dc.contributor.authorLillard Jr., J.
dc.date.issued2005
dc.descriptionCopyright © 2005, American Society for Microbiology
dc.description.abstractLarger numbers of pneumococci were detected in the nasal tract compared to the lung, cervical lymph nodes, and spleen 1, 2, 4, 7, 14, and 21 days after nasal challenge with Streptococcus pneumoniae strain EF3030. In this mouse model of pneumococcal carriage, peripheral S. pneumoniae pneumococcal surface adhesin A (PsaA)-specific humoral responses (immunoglobulin G2a [IgG2a] IgG1 = IgG2b > IgG3) were significantly higher than pneumococcal surface protein A (PspA)-specific, genetic toxoid derivative of pneumolysin (PdB)-specific, or pneumococcal surface protein C (PspC)-specific serum antibody levels. However, PspA-specific mucosal IgA antibody levels were significantly higher than those against PsaA, PdB, and PspC. In general, both PsaA- and PspA-specific lung-, cervical lymph node-, nasal tract-, and spleen-derived CD4+ T-cell cytokine (interleukin-4, interleukin-6, granulocyte-macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha) and proliferative responses were higher than those for either PspC or PdB. Taken together, these findings suggest that PsaA- and PspA-specific mucosal responses as well as systemic humoral and T helper cell cytokine responses are predominantly yet differentially induced during pneumococcal carriage.
dc.description.statementofresponsibilityRavichandran Palaniappan, Shailesh Singh, Udai P. Singh, Senthil Kumar K. Sakthivel, Edwin W. Ades, David E. Briles, Susan K. Hollingshead, James C. Paton, Jacquelyn S. Sampson, and James W. Lillard, Jr.
dc.identifier.citationInfection and Immunity, 2005; 73(2):1006-1013
dc.identifier.doi10.1128/IAI.73.2.1006-1013.2005
dc.identifier.issn0019-9567
dc.identifier.issn1098-5522
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/27470
dc.language.isoen
dc.publisherAmer Soc Microbiology
dc.source.urihttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=547096&rendertype=abstract
dc.subjectT-Lymphocyte Subsets
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectAnimals
dc.subjectMice
dc.subjectPneumococcal Infections
dc.subjectDisease Models, Animal
dc.subjectLipoproteins
dc.subjectBacterial Proteins
dc.subjectAdhesins, Bacterial
dc.subjectMembrane Transport Proteins
dc.subjectAntigens, Bacterial
dc.subjectCytokines
dc.subjectCell Division
dc.titleDifferential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage
dc.typeJournal article
pubs.publication-statusPublished

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