Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?

Simple item page
dc.contributor.authorKrisstiansson, P.
dc.contributor.authorHolding, C.
dc.contributor.authorHughes, S.
dc.contributor.authorHaynes, D.
dc.date.issued2005
dc.descriptionRelaxin and Related Peptides: Fourth International Conference / O.D. Sherwood, P.A. Fields, B.G. Steinetz (eds.): pp.317-319
dc.description.abstractThis study was designed to test the hypothesis that relaxin stimulates bone resorption by regulating the production of several mediators that stimulate osteoclast formation. The levels of mediators were measured in response to differing relaxin concentrations in supernatants from peripheral blood mononuclear cells (PBMCs), MCF-7 breast cancer cells, and normal human osteoblasts. Although all cell types expressed mRNA for the relaxin receptor (LGR7), only PBMCs responded to relaxin at physiologic levels by increasing tumor necrosis factor- and interleukin-1ß secretion. The findings indicate that PBMCs should be studied in relation to the effect of relaxin on inflammation and bone destruction caused by osteoclasts.
dc.identifier.citationAnnals of the New York Academy of Sciences, 2005; 1041(1):317-319
dc.identifier.doi10.1196/annals.1282.050
dc.identifier.issn0077-8923
dc.identifier.issn1749-6632
dc.identifier.urihttp://hdl.handle.net/2440/17169
dc.language.isoen
dc.publisherNew York Acad Sciences
dc.rights©2005 New York Academy of Sciences, all rights reserved.
dc.source.urihttps://doi.org/10.1196/annals.1282.050
dc.subjectrelaxin
dc.subjectbone resorption
dc.subjectPBMCs
dc.subjectmRNA
dc.titleDoes human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Pathology publications