Semantic memory and lexical availability in Parkinson's disease: a statistical learning study
Files
(Published version)
Date
2021
Authors
Cardona, J.F.
Grisales Cardenas, J.S.
Trujillo Llano, C.
Diazgranados, J.A.
Urquina, H.F.
Cardona, S.
Torres, A.
Torres, L.A.
Gonzalez, L.M.
Jaramillo, T.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Frontiers in Aging Neuroscience, 2021; 13(article no. 697065):1-11
Statement of Responsibility
Conference Name
Abstract
Parkinson’s disease (PD) is a neurodegenerative disorder that causes a progressive impairment in motor and cognitive functions. Although semantic fluency deficits have been described in PD, more specific semantic memory (SM) and lexical availability (LA) domains have not been previously addressed. Here, we aimed to characterize the cognitive performance of PD patients in a set of SM and LA measures and determine the smallest set of neuropsychological (lexical, semantic, or executive) variables that most accurately classify groups. Thirty early-stage non-demented PD patients (age 35–75, 10 females) and thirty healthy controls (age 36–76, 12 females) were assessed via general cognitive, SM [three subtests of the CaGi battery including living (i.e., elephant) and non-living things (i.e., fork)], and LA (eliciting words from 10 semantic categories related to everyday life) measures. Results showed that PD patients performed lower than controls in two SM global scores (picture naming and naming in response to an oral description). This impairment was particularly pronounced in the non-living things subscale. Also, the number of words in the LA measure was inferior in PD patients than controls, in both larger and smaller semantic fields, showing a more inadequate recall strategy. Notably, the classification algorithms indicated that the SM task had high classification accuracy. In particular, the denomination of non-living things had a classification accuracy of ∼80%. These results suggest that frontostriatal deterioration in PD leads to search strategy deficits in SF and the potential disruption in semantic categorization. These findings are consistent with the embodied view of cognition.
School/Discipline
Dissertation Note
Provenance
Description
Data source: Supplementary material, https://www.frontiersin.org/articles/10.3389/fnagi.2021.697065/full#supplementary-material
Access Status
Rights
Copyright 2021 Cardona, Grisales-Cardenas, Trujillo-Llano, Diazgranados, Urquina, Cardona, Torres, Torres, Gonzalez, Jaramillo, Cediel, Oñate-Cadena, Mateus-Ferro and Marmolejo-Ramos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.