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Widespread early dendritic injury associated with loss of cortical MAP-2 immunostaining in a focal ovine head impact model.

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dc.contributor.authorManavis, J.
dc.contributor.authorLee, P.L.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorLewis, S.
dc.contributor.authorFinnie, J.
dc.contributor.authorReilly, P.
dc.contributor.authorJones, N.
dc.date.issued1999
dc.description.abstractDendritic pathology associated with traumatic brain injury may be identified by microtubule associated protein-2 (MAP-2) immunohistochemistry. The aim of this study was to examine the dendritic response in the cerebral cortical mantle in an ovine head impact model using MAP-2 immunostaining as a marker for dendritic injury. The loss of cortical MAP-2 immunoreactivity at 2 h was recorded and quantitated using a computerised image analysis system applied to standard coronal brain sections obtained from 10 impacted and 3 control sheep. Coup and contrecoup cortical contusions were present in 9 of 10 impacted brains examined 2 h after injury. MAP-2 immunoreactivity was lost in all areas of cortical contusion irrespective of site and in otherwise histologically normal cortex. MAP-2 immunostaining was lost in over 45% of the whole cortical area (range 32-54%) and only 2% (range 0-5.5%) was associated with contusions. This study has shown that there is widespread loss of MAP-2 immunostaining following head impact in the cerebral cortical mantle (up to 54%) suggestive of early dendritic injury.
dc.description.statementofresponsibilityManavis, Jim ; Lee, Po-Ling ; Blumbergs, Peter C ; Lewis, Steve B ; Finnie, John W ; Reilly, Peter L ; Jones, Nigel R
dc.identifier.citationJournal of Clinical Neuroscience, 1999; 6(6):500-505
dc.identifier.doi10.1016/S0967-5868(99)90010-3
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.orcidManavis, J. [0000-0001-7381-7781] [0000-0003-1268-561X]
dc.identifier.orcidFinnie, J. [0000-0003-2277-1693]
dc.identifier.urihttp://hdl.handle.net/2440/10165
dc.language.isoen
dc.publisherCHURCHILL LIVINGSTONE
dc.source.urihttps://doi.org/10.1016/s0967-5868(99)90010-3
dc.titleWidespread early dendritic injury associated with loss of cortical MAP-2 immunostaining in a focal ovine head impact model.
dc.typeJournal article
pubs.publication-statusPublished

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