Relating intercellular variability in nanoparticle uptake with biological consequence: a quantitative x-ray fluorescence study for radiosensitization of cells

Date

2015

Authors

Turnbull, T.
Douglass, M.
Paterson, D.
Bezak, E.
Thierry, B.
Kempson, I.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

Analytical Chemistry, 2015; 87(21):10693-10697

Statement of Responsibility

Tyron Turnbull, Michael Douglass, David Paterson, Eva Bezak, Benjamin Thierry, and Ivan Kempson

Conference Name

DOI

10.1021/acs.analchem.5b03183

Abstract

Internalized gold nanoparticles were quantified in large numbers of individual prostate cancer cells using large area synchrotron X-ray fluorescence microscopy. Cells were also irradiated with a 6 MV linear accelerator to assess the biological consequence of radiosensitization with gold nanoparticles. A large degree of heterogeneity in nanoparticle uptake between cells resulted in influenced biological effect.

School/Discipline

Dissertation Note

Provenance

Description

Data source: Supporting information, http://pubs.acs.org/doi/suppl/10.1021/acs.analchem.5b03183

Access Status

Rights

© 2015 American Chemical Society

License

Grant ID

http://purl.org/au-research/grants/nhmrc/1045841

Published Version

https://doi.org/10.1021/acs.analchem.5b03183

Call number

Persistent link to this record

http://hdl.handle.net/2440/100249