Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly
Date
2001
Authors
Beckoff, K.
MacIntosh, C.
Chapman, I.
Wishart, J.
Morris, H.
Horowitz, M.
Jones, K.
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Journal article
Citation
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2001; 280(2):R570-R576
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Katherine Beckoff, Caroline G. MacIntosh, Ian M. Chapman, Judith M. Wishart, Howard A. Morris, Michael Horowitz, and Karen L. Jones
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Abstract
The aims of this study were to evaluate the effects of dietary glucose supplementation on gastric emptying (GE) of both glucose and fat, postprandial blood glucose homeostasis, and appetite in eight older subjects (4 males, 4 females, aged 65–84 yr). GE of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the GE study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). Glucose supplementation accelerated GE of glucose (P , 0.05), but not oil; there was a trend for an increase in GIP (at 15 min, P 5 0.06), no change in GLP-1, an earlier insulin peak (P , 0.01), and a subsequent reduction in blood glucose (at 75 min, P , 0.01). Glucose supplementation had no effect on food intake during each diet so that energy intake was greater (P , 0.001) during the glucose-supplemented diet. Appetite ratings and energy intake at the buffet meal were not different. We conclude that, in older subjects, glucose supplementation 1) accelerates GE of glucose, but not fat; 2) modifies postprandial blood glucose homeostasis; and 3) increases energy intake.
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Published abstract used with permission of the copyright owner.
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Copyright © 2001 American Physiological Society