Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil
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(Published version)
Date
2022
Authors
Kim, S.
Fouladian, P.
Afinjuomo, F.
Song, Y.
Youssef, S.H.
Vaidya, S.
Garg, S.
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Journal article
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International Journal of Pharmaceutics, 2022; 611(121316)
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Abstract
Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to overcome the shortcomings of commercial cream for the treatment of non-melanoma skin cancer (NMSC). Plasticizers are a critical component of drug-in-adhesive (DIA) patches as they can significantly affect the mechanical, adhesive and drug release characteristics of the patches. Eudragit® E (EuE) is a methacrylate-based cationic copolymer capable of producing flexible and adhesive films for topical application. In this study, the effect of plasticizers on the mechanical, adhesive and 5-FU release characteristics of EuE-based patches was comprehensively evaluated. While the elongation at break (%) and adhesion of the films were significantly increased with increasing triacetin, dibutyl sebacate (DBS) and triethyl citrate (TEC) concentrations, the tensile strength showed an inverse relationship. EuE plasticized with 40% triacetin, 30% DBS or 40% w/w TEC produced elastic and adhesive films most suitable for topical application. In vitro release studies of the 5-FU-loaded patches demonstrated an initial burst release pattern during the first 10 min followed by a slow release over 120 min. In summary, this study provides important information on effect of plasticizers for preparation of EuE-based patches with desired mechanical, adhesive and release characteristics of 5-FU towards their potential application in the treatment of NMSC.
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Data source: Supplementary data, https://doi.org/10.1016/j.ijpharm.2021.121316
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Copyright 2022 Elsevier
Access Condition Notes: Accepted manuscript available after 1 January 2023