Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

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dc.contributor.authorZewail, M.B.
dc.contributor.authorYang, G.
dc.contributor.authorFan, Y.
dc.contributor.authorHui, Y.
dc.contributor.authorZhao, C.
dc.contributor.authorLiu, Y.
dc.date.issued2025
dc.description.abstractCell membrane coating (CMC) of nanoparticles (NPs) has emerged as a prominent strategy that has gained significant attention and achieved notable progress across various therapeutic sectors. Coating NPs with natural cell membranes endows them with various functions and addresses various challenges in drug delivery, such as prolonging circulation time, reducing immunogenicity, and improving targeting efficiency and cellular communication. Among the different NPs, lipid nanoparticles (LNPs) have revolutionized the field of nanomedicine by providing various advantageous features for drug delivery. The versatile characteristics of LNPs synergize well with cell membranes’ biomimetic properties, creating hybrid structures with enhanced functionalities for diverse biomedical applications. A more advanced form of LNPs with significantly enhanced capabilities can be achieved through CMC. However, significant opportunities remain for further advancements, with ongoing efforts focused on discovering innovative applications and fully harnessing the potential of this promising combination. This article provides a critical review of recent progress in cell membrane coated-LNPs (CMC-LNPs). First, different LNP types, their preparation methods, and coating strategies are summarized. The development, properties, functions, and applications of CMC-LNPs are then discussed. Last, their advantages, limitations, challenges, and future perspectives are presented.
dc.description.statementofresponsibilityMoataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun-Xia Zhao, Yun Liu
dc.identifier.citationAggregate, 2025; 6(7):e70054-1-e70054-45
dc.identifier.doi10.1002/agt2.70054
dc.identifier.issn2766-8541
dc.identifier.issn2692-4560
dc.identifier.orcidYang, G. [0000-0002-6194-1918]
dc.identifier.orcidHui, Y. [0000-0002-1057-5671]
dc.identifier.orcidLiu, Y. [0000-0003-1320-139X]
dc.identifier.urihttps://hdl.handle.net/2440/147286
dc.language.isoen
dc.publisherWiley
dc.relation.granthttp://purl.org/au-research/grants/arc/DE230101044
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2008698)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2034857
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2026797
dc.rights© 2025 The Author(s). Aggregate published by SCUT, AIEI, and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1002/agt2.70054
dc.subjectcell membrane coating; drug delivery; lipid nanoparticles; surface modification; targeted delivery
dc.titleCell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
dc.typeJournal article
pubs.publication-statusPublished online

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