Highly stable nanocontainer of APTES-anchored layered titanate nanosheet for reliable protection/recovery of nucleic acid
Date
2016
Authors
Kim, T.W.
Kim, I.Y.
Park, D.H.
Choy, J.H.
Hwang, S.J.
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Journal article
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Scientific Reports, 2016; 6(21993):1-12
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Abstract
A universal technology for the encapsulative protection of unstable anionic species by highly stable layered metal oxide has been developed via the surface modification of a metal oxide nanosheet. The surface anchoring of (3-aminopropyl) triethoxysilane (APTES) on exfoliated titanate nanosheet yields a novel cationic metal oxide nanosheet, which can be universally used for the hybridization with various biological and inorganic anions. The encapsulation of deoxyribonucleic acid (DNA) in the cationic APTES-anchored titanate lattice makes possible the reliable long-term protection of DNA against enzymatic, chemical, and UV−vis light corrosions.
The encapsulated DNA can be easily released from the titanate lattice via sonication, underscoring the functionality of the cationic APTES-anchored titanate nanosheet as a stable nanocontainer for DNA. The APTES-anchored titanate nanosheet can be also used as an efficient CO2 adsorbent and a versatile host material for various inorganic anions like polyoxometalates, leading to the synthesis of novel intercalative nanohybrids with unexplored properties and useful functionalities.
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Data source: Supplementary data, https://images.nature.com/original/nature-assets/srep/2016/160224/srep21993/extref/srep21993-s1.pdf
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