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The role of intracoronary imaging in translational research

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dc.contributor.authorMontarello, N.J.
dc.contributor.authorNelson, A.J.
dc.contributor.authorVerjans, J.
dc.contributor.authorNicholls, S.J.
dc.contributor.authorPsaltis, P.J.
dc.date.issued2020
dc.description.abstractAbstract: Atherosclerotic cardiovascular disease is a key public health concern worldwide and leading cause of morbidity, mortality and health economic costs. Understanding atherosclerotic plaque microstructure in relation to molecular mechanisms that underpin its initiation and progression is needed to provide the best chance of combating this disease. Evolving vessel wall-based, endovascular coronary imaging modalities, including intravascular ultrasound (IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS), used in isolation or as hybrid modalities, have been advanced to allow comprehensive visualization of the pathological substrate of coronary atherosclerosis and accurately measure temporal changes in both the vessel wall and plaque characteristics. This has helped further our appreciation of the natural history of coronary artery disease (CAD) and the risk for major adverse cardiovascular events (MACE), evaluate the responsiveness to conventional and experimental therapeutic interventions, and assist in guiding percutaneous coronary intervention (PCI). Here we review the use of different imaging modalities for these purposes and the lessons they have provided thus far.
dc.description.statementofresponsibilityNicholas J. Montarello, Adam J. Nelson, Johan Verjans, Stephen J. Nicholls, Peter J. Psaltis
dc.identifier.citationCardiovascular Diagnosis and Therapy, 2020; 10(5):1480-1507
dc.identifier.doi10.21037/cdt-20-1
dc.identifier.issn2223-3652
dc.identifier.issn2223-3660
dc.identifier.orcidNelson, A.J. [0000-0003-0990-2548]
dc.identifier.orcidVerjans, J. [0000-0002-8336-6774]
dc.identifier.orcidNicholls, S.J. [0000-0002-9668-4368]
dc.identifier.orcidPsaltis, P.J. [0000-0003-0222-5468]
dc.identifier.urihttp://hdl.handle.net/2440/129665
dc.language.isoen
dc.publisherAME Publishing Company
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1111630
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/APP1161506
dc.rights© Cardiovascular Diagnosis and Therapy. All rights reserved. This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.source.urihttps://doi.org/10.21037/cdt-20-1
dc.subjectCoronary artery disease (CAD); intracoronary imaging; intravascular ultrasound (IVUS); near-infrared spectroscopy (NIRS); optical coherence tomography (OCT); plaque imaging
dc.titleThe role of intracoronary imaging in translational research
dc.typeJournal article
pubs.publication-statusPublished

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