Supersaturated silica-lipid hybrids : overcoming the challenges of oral drug delivery /
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(Published version)
Date
2020
Authors
Schultz, Hayley
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thesis
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Abstract
Poorly water-soluble drugs emerging from drug discovery programs pose significant oral delivery challenges, requiring formulation strategies to improve bioavailability. While lipid-based formulations are an enabling delivery strategy, their clinical translation is limited due to stability concerns and low drug loading. This thesis investigated the development of supersaturated silica-lipid hybrid formulations to overcome the limitations associated with lipid-based formulations and to improve bioavailability. This novel approach demonstrated enhanced solubilisation and bioavailability for the model drug ibuprofen and the cancer drug abiraterone acetate, exceeding the performance of their commercial products. Knowledge gained from this thesis can be harnessed to guide future research into the further development and application of supersaturated solid-state lipid-based formulations.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences
School of Pharmacy and Medical Sciences
Dissertation Note
Thesis (PhD(Pharmaceutical Science))--University of South Australia, 2020.
Provenance
Copyright 2020 Hayley Beth Schultz.
Description
1 ethesis (145 pages) :
illustrations (chiefly colour)
Includes bibliographical references (pages 124-135)
Recipient of the 2021 Ian Davey Research Thesis Prize (UniSA)
illustrations (chiefly colour)
Includes bibliographical references (pages 124-135)
Recipient of the 2021 Ian Davey Research Thesis Prize (UniSA)
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