Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia
Date
2024
Authors
Ong, K.O.K.
Mok, M.M.H.
Niibori-Nambu, A.
Du, L.
Yanagida, M.
Wang, C.Q.
Bahirvani, A.G.
Chin, D.W.L.
Koh, C.P.
Ng, K.P.
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Journal article
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Experimental Hematology, 2024; 137(104255)
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Abstract
The genetic lesions that drive acute megakaryoblastic leukemia (AMKL) have not been fully elucidated. To search for genetic alterations in AMKL, we performed targeted deep sequencing in 34 AMKL patient samples and 8 AMKL cell lines and detected frequent genetic mutations in the NOTCH pathway in addition to previously reported alterations in GATA-1 and the JAK-STAT pathway. Pharmacological and genetic NOTCH activation, but not inhibition, significantly suppressed AMKL cell proliferation in both in vitro and in vivo assays employing a patient-derived xenograft model. These results suggest that NOTCH inactivation underlies AMKL leukemogenesis. and NOTCH activation holds the potential for therapeutic application in AMKL.
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Data source: Supporting information, https://doi.org/10.1016/j.exphem.2024.104255
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Copyright 2024 International Society for Experimental Hematology