Genetic loci influencing kidney function and chronic kidney disease
Date
2010
Authors
Chambers, J.C.
Zhang, W.
Lord, G.M.
Van der Harst, P.
Hypponen, E.
Kooner, J.S.
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Journal article
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Nature Genetics, 2010; 42(5):373-375
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Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10−10 to 10−15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10−5 and P = 3.6 × 10−4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
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Link to a related website: http://europepmc.org/articles/pmc3748585?pdf=render, Open Access via Unpaywall
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Copyright 2010 Nature Publishing Group