New developments in the pharmacologic management of posttraumatic oedema
Date
2004
Authors
Vink, R.
Editors
Advisors
Journal Title
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Type:
Conference paper
Citation
7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.55-60
Statement of Responsibility
R. Vink
Conference Name
International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.)
Abstract
A major risk factor contributing to increased mortality and morbidity following traumatic brain injury (TBI) is oedema formation. Recent efforts by our laboratory, and others, have concentrated on establishing the mechanisms associated with oedema formation following brain injury, and developing appropriate pharmacologic interventional therapies. Our own studies to date have shown that neurogenic inflammation is a major contributor to brain oedema formation. Attenuation of the neurogenic inflammation, either by preventing release of the neuropeptides or blocking substance P receptor binding, profoundly inhibited these events. We propose that pharmacologic intervention targeting neurogenic inflammation may be a promising strategy for the management of posttraumatic oedema.
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© 2004 by MEDIMOND The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included.