Microwave assisted ligand free palladium catalyzed synthesis of β-arylalkenyl nitriles using water as solvent

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2010

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Velmathi, S.
Vijayaraghavan, R.
Pal, R.P.
Vinu, A.

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Catalysis Letters, 2010; 135(1):148-151

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We have developed a rapid and efficient method for the synthesis of β-arylalkenyl nitriles by one pot three component coupling reaction of diphenyl acetylene, K4(Fe)CN6, and aryl halides using Pd(OAc)2 as a catalyst and water as a solvent under microwave irradiation. The method is very simple and attractive as it requires only a shorted reaction time and employs cyanide source which is safe and inexpensive.

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Copyright 2010 Springer Science+Business Media, LLC.

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