An orphaned mammalian b-globin gene of ancient evolutionary origin

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dc.contributor.authorWheeler, D.
dc.contributor.authorHope, R.
dc.contributor.authorCooper, S.
dc.contributor.authorDolman, G.
dc.contributor.authorWebb, G.
dc.contributor.authorBottema, C.
dc.contributor.authorGooley, A.
dc.contributor.authorGoodman, M.
dc.contributor.authorHolland, R.
dc.date.issued2001
dc.description© 2001 National Academy of Sciences
dc.description.abstractMammals possess multiple, closely linked β-globin genes that differ in the timing of their expression during development. These genes have been thought to be derived from a single ancestral gene, by duplication events that occurred after the separation of the mammals and birds. We report the isolation and characterization of an atypical β-like globin gene (ω-globin) in marsupials that appears to be more closely related to avian β-globin genes than to other mammalian β-globin genes, including those previously identified in marsupials. Phylogenetic analyses indicate that ω-globin evolved from an ancient gene duplication event that occurred before the divergence of mammals and birds. Furthermore, we show that ω-globin is unlinked to the previously characterized β-globin gene cluster of marsupials, making this the first report of an orphaned β-like globin gene expressed in a vertebrate.
dc.description.statementofresponsibilityDavid Wheeler; Rory Hope; Steven J. B. Cooper; Gaynor Dolman; Graham C. Webb; Cynthia D. K. Bottema; Andrew A. Gooley; Morris Goodman and Robert A. B. Holland
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2001; 98(3):1101-1106
dc.identifier.doi10.1073/pnas.98.3.1101
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.orcidCooper, S. [0000-0002-7843-8438]
dc.identifier.orcidDolman, G. [0000-0001-7611-6841]
dc.identifier.orcidBottema, C. [0000-0001-6245-0099]
dc.identifier.urihttp://hdl.handle.net/2440/13292
dc.language.isoen
dc.publisherNatl Acad Sciences
dc.source.urihttp://www.jstor.org/stable/3054828
dc.subjectAnimals
dc.subjectMammals
dc.subjectMarsupialia
dc.subjectHumans
dc.subjectGlobins
dc.subjectCloning, Molecular
dc.subjectPolymerase Chain Reaction
dc.subjectSequence Alignment
dc.subjectEvolution, Molecular
dc.subjectPhylogeny
dc.subjectGene Duplication
dc.subjectAmino Acid Sequence
dc.subjectBase Sequence
dc.subjectMolecular Sequence Data
dc.titleAn orphaned mammalian b-globin gene of ancient evolutionary origin
dc.typeJournal article
pubs.publication-statusPublished

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