Stimulation and Repair of Peripheral Nerves Using Bioadhesive Graft-Antenna

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dc.contributor.authorSliow, A.
dc.contributor.authorMa, Z.
dc.contributor.authorGargiulo, G.
dc.contributor.authorMahns, D.
dc.contributor.authorMawad, D.
dc.contributor.authorBreen, P.
dc.contributor.authorStoodley, M.
dc.contributor.authorHouang, J.
dc.contributor.authorKuchel, R.
dc.contributor.authorTettamanzi, G.C.
dc.contributor.authorTilley, R.D.
dc.contributor.authorFrost, S.J.
dc.contributor.authorMorley, J.
dc.contributor.authorLongo, L.
dc.contributor.authorLauto, A.
dc.date.issued2019
dc.description.abstractAn original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft-antenna). The graft-antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft-antenna and stimulated by the TMS for 1 h per week. The graft-antenna is an innovative and minimally- invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.
dc.description.statementofresponsibilityAshour Sliow, Zhi Ma, Gaetano Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Rhiannon Kuchel, Giuseppe C. Tettamanzi, Richard D. Tilley, Samuel J. Frost, John Morley, Leonardo Longo, and Antonio Lauto
dc.identifier.citationAdvanced Science, 2019; 6(11):1801212-1-1801212-13
dc.identifier.doi10.1002/advs.201801212
dc.identifier.issn2198-3844
dc.identifier.issn2198-3844
dc.identifier.orcidTettamanzi, G.C. [0000-0002-3209-0632]
dc.identifier.urihttps://hdl.handle.net/2440/146438
dc.language.isoen
dc.publisherWiley
dc.rights© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1002/advs.201801212
dc.subjectchitosan; lasers; nerve stimulators; photochemical tissue bonding; wireless antenna
dc.titleStimulation and Repair of Peripheral Nerves Using Bioadhesive Graft-Antenna
dc.typeJournal article
pubs.publication-statusPublished

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