Early Cure Rates with Narrow-Margin Slow-Mohs Surgery for Periocular Malignant Melanoma

Simple item page
dc.contributor.authorThen, S.
dc.contributor.authorMalhotra, R.
dc.contributor.authorBarlow, R.
dc.contributor.authorKurwa, H.
dc.contributor.authorHuilgol, S.
dc.contributor.authorJoshi, N.
dc.contributor.authorOlver, J.
dc.contributor.authorCollin, J.
dc.contributor.authorSelva-Nayagam, D.
dc.date.issued2009
dc.description© 2009 American Society of Dermatologic Surgery
dc.description.abstract<h4>Background</h4>Staged excision with rush-processed paraffin-embedded tissue sections (Slow-Mohs) is an effective treatment for periocular melanoma. Although there is no consensus on initial margins of excision, narrower margins in the eyelids have the functionally and cosmetically important consequence of smaller postoperative wounds.<h4>Objectives</h4>To report early cure rates for periocular melanoma using Slow-Mohs surgery with en-face margin sectioning.<h4>Methods</h4>Retrospective, multicenter, noncomparative case series. Slow-Mohs surgery in 14 patients with periocular melanoma from 2000 to 2006.<h4>Results</h4>Fourteen patients underwent 14 Slow-Mohs procedures for eight lentigo maligna, one nodular, and one superficial spreading melanoma, and four lentigo maligna, 12 primary, and two recurrent tumors. The most common site was the lower eyelid (8/14, 57.1%). Breslow thickness ranged from 0.27 to 1.70 mm, with four cases less than 0.76 mm and one case greater than 1.5 mm. Five cases were a Clark level II or greater. Complete excision was achieved with one level (6 cases) or two or three levels (8 cases), with 2- to 3-mm margins at each level in all but one case. With median follow-up of 36 months, there were two local recurrences (2/14, 14.3%).<h4>Conclusion</h4>Slow-Mohs with en-face sections achieves similar early cure rates to previously published margin-controlled excision techniques. Narrow margins of excision can optimize tissue preservation without compromising outcome.
dc.description.statementofresponsibilitySiew-Yin Then, Raman Malhotra, Richard Barlow, Habib Kurwa, Shyamala Huilgol, Naresh Joshi, Jane Olver, Richard Collin, and Dinesh Selva
dc.identifier.citationDermatologic Surgery, 2009; 35(1):17-23
dc.identifier.doi10.1111/j.1524-4725.2008.34377.x
dc.identifier.issn1076-0512
dc.identifier.issn1524-4725
dc.identifier.orcidHuilgol, S. [0000-0001-6668-1230]
dc.identifier.orcidSelva-Nayagam, D. [0000-0002-2169-5417]
dc.identifier.urihttp://hdl.handle.net/2440/50946
dc.language.isoen
dc.publisherBlackwell Science Inc
dc.source.urihttps://doi.org/10.1111/j.1524-4725.2008.34377.x
dc.subjectEye
dc.subjectHumans
dc.subjectMelanoma
dc.subjectHutchinson's Melanotic Freckle
dc.subjectFacial Neoplasms
dc.subjectEyelid Neoplasms
dc.subjectTreatment Outcome
dc.subjectMohs Surgery
dc.subjectRetrospective Studies
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleEarly Cure Rates with Narrow-Margin Slow-Mohs Surgery for Periocular Malignant Melanoma
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications