Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host Models, and Translational Significance
Date
2024
Authors
Thompson, J.
Saad, M.I.
Editors
Saad, M.I.
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Book chapter
Citation
Patient-Derived Xenografts : Methods and Protocols, 2024 / Saad, M.I. (ed./s), vol.2806, Ch.1, pp.1-8
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James Thompson and Mohamed I. Saad
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Abstract
Patient-derived xenografts (PDXs) represent a critical advancement in preclinical cancer research, wherein human tumor samples are implanted into animal models for evaluation of therapeutic responses. PDXs have emerged as indispensable tools in translational cancer research, facilitating investigation into tumor microenvironments and personalized medicine. This chapter elucidates the historical evolution of PDXs, from early attempts in the eighteenth century to contemporary immunocompromised host models that enhance engraftment success.
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© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024