Healing wounds with plasma-activated hydrogel therapy

Date

2025

Authors

Sabrin, S.
Hong, S.-H.
Karmokar, D.K.
Habibullah, H.
Fitridge, R.
Short, R.D.
Szili, E.J.

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Journal article

Citation

Trends in Biotechnology, 2025; 43(2):278-289

Statement of Responsibility

Sumyea Sabrin, Sung-Ha Hong, Debabrata K. Karmokar, Habibullah Habibullah, Robert Fitridge, Robert D. Short, and Endre J. Szili

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Abstract

Chronic wound infections are a silent pandemic in danger of becoming a global healthcare crisis. Innovations to control infections and improve healing are required. In the context of this challenge, researchers are exploiting plasma-activated hydrogel therapy (PAHT) for use either alone or in combination with other antimicrobial strategies. PAHT involves the cold atmospheric pressure plasma activation of hydrogels with reactive oxygen and nitrogen species to decontaminate infections and promote healing. This opinion article describes PAHT for wound treatment and provides an overview of current research and outstanding challenges in translating the technology for medical use. A 'blueprint' of an autonomous PAHT is presented in the final section that can move the management and treatment of wounds from the clinical setting to the community.

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Published online August 28, 2024

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© 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

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