Withdrawal of antihypertensive drugs in older people
Date
2025
Authors
Gnjidic, D.
Langford, A.V.
Jordan, V.
Sawan, M.
Sheppard, J.P.
Thompson, W.
Todd, A.
Hopper, I.
Hilmer, S.N.
Reeve, E.
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Journal article
Citation
The Clinical Respiratory Journal, 2025; 2025(3):1-66
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Abstract
Hypertension is an important risk factor for subsequent cardiovascular events, including ischaemic and haemorrhagic stroke, myocardialinfarction, and heart failure, as well as chronic kidney disease, cognitive decline, and premature death. Overall, the use of antihypertensive medications has led to a reduction in cardiovascular disease, morbidity rates, and mortality rates. However, the use of antihypertensive medications is also associated with harms, especially in older people, including the development of adverse drug reactions and drug-drug interactions, and can contribute to increasing medication-related burden. As such, discontinuation of antihypertensives may be considered appropriate in some older people.
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Data source: Download data, https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012572.pub3/media/CDSR/CD012572/supinfo/CD012572-dataPackage.zip?content-disposition=attachment&mime-type=application/octet-stream
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Copyright 2025 The Cochrane Collaboration.