Nutriomes and personalised nutrition for DNA damage prevention, telomere integrity maintenance and cancer growth control
Date
2014
Authors
Fenech, M.F.
Editors
Zappia, V.
Panico, S.
Russo, G.
Budillon, A.
Fulvio Della Ragione,
Panico, S.
Russo, G.
Budillon, A.
Fulvio Della Ragione,
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Book chapter
Citation
Advances in nutrition and cancer, 2014 / Zappia, V., Panico, S., Russo, G., Budillon, A., Fulvio Della Ragione, (ed./s), vol.159, Ch.24, pp.427-441
Statement of Responsibility
Michael F. Fenech
Conference Name
Abstract
DNA damage at the base sequence and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage and genomic instability rates. The challenge is to identify for each individual the combination of micronutrients and their doses (i.e. the nutriome) that optimises genome stability, including telomere integrity and functionality and DNA repair. Using nutrient array systems with high-content analysis diagnostics of DNA damage, cell death and cell growth, it is possible to define, on an individual basis, the optimal nutriome for DNA damage prevention and cancer growth control. This knowledge can also be used to improve culture systems for cells used in therapeutics such as stem cells to ensure that they are not genetically aberrant when returned to the body. Furthermore, this information could be used to design dietary patterns that deliver the micronutrient combinations and concentrations required for preventing DNA damage by micronutrient deficiency or excess. Using this approach, new knowledge could be obtained to identify the dietary restrictions and/or supplementations required to control specific cancers, which is particularly important given that reliable validated advice is not yet available for those diagnosed with cancer.
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© Springer-Verlag Berlin Heidelberg 2014