Current studentsExisting staffContact us
 

Effect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain

Simple item page
dc.contributor.authorFinnie, J.
dc.contributor.authorBlumbergs, P.
dc.contributor.authorCai, Z.
dc.contributor.authorManavis, J.
dc.contributor.authorKuchel, T.
dc.date.issued2006
dc.description.abstract<h4>Aims</h4>To study the effect of mobile telephone exposure on blood-brain barrier (BBB) permeability in the immature brain.<h4>Methods</h4>Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exposure at a specific absorption rate of 4 W/kg for 60 min/day from day 1 to day 19 of gestation. Pregnant control mice were sham-exposed or freely mobile in a cage without further restraint and a positive control group with cadmium-induced BBB damage was also included. Immediately prior to parturition on gestational day 19, fetal heads were collected, fixed in Bouin's fixative and paraffin embedded. Disruption of BBB integrity was detected immunohistochemically using endogenous albumin as a vascular tracer in cerebral cortex, thalamus, basal ganglia, hippocampus, cerebellum, midbrain and medulla.<h4>Results</h4>No albumin extravasation was found in exposed or control brains.<h4>Conclusion</h4>In this animal model, whole of gestation exposure to global system for mobile communication-like radiofrequency fields did not produce any increase in vascular permeability in the fetal brain regions studied using endogenous albumin as a light microscopic immunohistochemical marker.
dc.identifier.citationPathology, 2006; 38(1):63-65
dc.identifier.doi10.1080/00313020500459607
dc.identifier.issn0031-3025
dc.identifier.issn1465-3931
dc.identifier.orcidFinnie, J. [0000-0003-2277-1693]
dc.identifier.orcidManavis, J. [0000-0001-7381-7781] [0000-0003-1268-561X]
dc.identifier.urihttp://hdl.handle.net/2440/23339
dc.language.isoen
dc.publisherTaylor & Francis
dc.source.urihttps://doi.org/10.1080/00313020500459607
dc.subjectBlood-Brain Barrier
dc.subjectBrain
dc.subjectMesencephalon
dc.subjectCerebellum
dc.subjectHippocampus
dc.subjectThalamus
dc.subjectCerebral Cortex
dc.subjectAnimals
dc.subjectMice, Inbred BALB C
dc.subjectMice
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectCadmium
dc.subjectAlbumins
dc.subjectImmunohistochemistry
dc.subjectModels, Animal
dc.subjectCell Membrane Permeability
dc.subjectPregnancy
dc.subjectRadio Waves
dc.subjectFemale
dc.subjectCell Phone
dc.titleEffect of mobile telephony on blood-brain barrier permeability in the fetal mouse brain
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications