Interaction between HIV-1 and APOBEC3 sub-family of proteins

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dc.contributor.authorArriaga, M.
dc.contributor.authorCarr, J.
dc.contributor.authorLi, P.
dc.contributor.authorWang, B.
dc.contributor.authorSaksena, N.
dc.date.issued2006
dc.description.abstractA variety of mechanisms of innate immunity that protect organisms from retroviral infections, including HIV, are known. Lentiviruses express viral infectivity factor (Vif) protein that has the ability to counter antiviral activity exhibited by the recently discovered host cytidine deaminases APOBEC3G and 3F. Although these host factors are present in diverse mammalian species and have been shown to act against various organisms, their importance in HIV infection has been highlighted because of their suggested activities against HIV in vivo and the strong conservation of the HIV vif gene encoding the Vif protein capable of countering this innate activity. The main purpose of this review is to provide a detailed overview on HIV-specific interaction of APOBEC3 subfamily of proteins and discuss its potential role in HIV pathogenesis.
dc.description.statementofresponsibilityMaria E. Arriaga, Jillian Carr, Peng Li, Bin Wang and Nitin K. Saksena
dc.identifier.citationCurrent HIV Research, 2006; 4(4):401-409
dc.identifier.doi10.2174/157016206778560063
dc.identifier.issn1570-162X
dc.identifier.issn1873-4251
dc.identifier.urihttp://hdl.handle.net/2440/24080
dc.language.isoen
dc.publisherBentham Science Publishers Ltd.
dc.rightsCopyright (c) 2009 Institute for Scientific Information
dc.source.urihttps://doi.org/10.2174/157016206778560063
dc.subjectHumans
dc.subjectHIV-1
dc.subjectHIV Infections
dc.subjectCytidine Deaminase
dc.subjectCytosine Deaminase
dc.subjectGene Products, vif
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectvif Gene Products, Human Immunodeficiency Virus
dc.subjectAPOBEC Deaminases
dc.titleInteraction between HIV-1 and APOBEC3 sub-family of proteins
dc.typeJournal article
pubs.publication-statusPublished

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