Prognostic value of Her-2/neu and clinicopathologic factors for evaluating progression and disease-specific death in Chinese men with prostate cancer
Date
2011
Authors
Zhang, Y.F.
Guan, Y.B.
Yang, B.
Wu, H.Y.
Dai, Y.T.
Zhang, S.J.
Wang, J.P.
Anoopkumar Dukie, S.
Davey, A.K.
Sun, Z.Y.
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Journal article
Citation
National Medical Journal of China, 2011; 124(24):4345-4349
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Abstract
Background Her-2/neu gene overexpression has been found in several malignancies,and is associated with poor prognosis; while its role in the tumorigenesis and progression of prostate cancer (PCa) is still controversial.This study aimed to evaluate the prognostic value of Her-2/neu protein expression and clinicopathologic factors in antiandrogen-treated Chinese men with PCa for disease progression and PCa-specific death.Methods Her-2/neu protein expression was determined using immunohistochemistry (IHC) in specimens collected from 124 prostate biopsies and transurethral resection of prostate (TURP) from seven prostate cancer patients.Results Her-2/neu protein expression was 0,1+,2+,and 3+ in 40 (30.5％),8 (6.1％),67 (51.1％),and 16 (12.2％) cases,respectively.Her-2/neu protein expression showed significant correlation as judged by Gleason score (P=0.049),clinical tumor-node-metastases (cTNM) stage (P=0.018) and disease progression (P=0.001),but did not correlate with prostate-specific antigen (PSA) (P=0.126) or PCa-specific death (P=0.585).PSA (P=0.001),Gleason score (P=0.017),cTNM (P=0.000) and Her-2/neu protein expression (P=0.001) had prognostic value for evaluating the progression of PCa in univariate analysis.In Kaplan-Meier plots,both Gleason score (P=0.035) and cTNM (P=0.013) correlated with PCa-specific death.In multivariate analysis,only cTNM was significant for both disease progression (P=0.001) and PCa-specific death (P=0.031).Conclusions Her-2/neu protein expression is significantly correlated with Gleason score,cTNM and disease progression,although it is not an independent predictor of disease progression and PCa-specific death.cTNM staging serves as an independent prognostic factor for disease progression and PCa-specific death.
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Copyright 2011 Medknow Publications and Media
Access Condition Notes: Article in Chinese, abstract only in English