The Biology and Pathogenesis of Chronic Myeloid Leukaemia
Date
2021
Authors
Shanmuganathan, N.
Chereda, B.
Melo, J.V.
Editors
Hehlmann, R.
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Book chapter
Citation
Chronic Myeloid Leukemia, 2021 / Hehlmann, R. (ed./s), Ch.2, pp.17-36
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Naranie Shanmuganathan, Bradley Chereda, Junia V. Melo
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Abstract
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder of the pluripotent stem cell. Understanding the molecular biology of CML began with the discovery of the Philadelphia (Ph) chromosome. This genomic abnormality is the result of a t(9;22) translocation, leading to the fusion oncogene, BCR-ABL1. The resulting protein is capable of hijacking a vast repertoire of cellular functions that drive myeloid hyperplasia, characteristic of the initial, chronic phase of the disease. However, the mechanisms of resistance and disease progression are less well defined. In this chapter, we explore the various pathways involved in the pathogenesis of CML and also the biological events underpinning progression to the more advanced stages of the disease.
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© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021