A multivariate exploration of the South Australian prenatal Down's syndrome screen / Brent Henderson.
Date
1998
Authors
Henderson, Brent
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Thesis
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Abstract
This thesis considers several aspects of multivariate analysis motivated by the South Australian prenatal Down's syndrome screen, which seeks to identify those pregnancies at high risk to Down's syndrome from several risk factors, amongst them maternal age and measurements from four analyte concentrations found in maternal blood. The primary aim is to discriminate between the unaffected and affected pregnancies in terms of these observed risk factors. Through the development of multivariate regression models it is examined how the Mahalanobis distance might be decomposed into distances that give more insight into where the discrimination is derived and how this might change with the gestational age at which the analyte concentrations are measured. A second multivariate aspect motivated by the screen surrounds the detection of directional outliers and the incorporation of knowledge of likely departures into the outlier identification technique. A method is also developed to account for misreporting in inferences of gestational age. Similarities with measurement error and misclassification models are explored.
School/Discipline
Dept. of Statistics
Dissertation Note
Thesis (Ph.D.)--University of Adelaide, Dept. of Statistics, 1998?
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Description
Bibliography: leaves 223-229.
xiii, 229 leaves : ill. ; 30 cm.
xiii, 229 leaves : ill. ; 30 cm.