Functionalized magnetite nanoparticles-synthesis, properties, and bioapplications
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2009
Authors
Majewski, P.
Thierry, B.
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Sigmund, W.
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Book chapter
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Source details - Title: Particulate systems in nano and biotechnologies, 2009 / Sigmund, W. (ed./s), Ch.15, pp.331-352
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Abstract
In recent years, functional nanostructures such as superparamagnetic nanoparticles, quantum dots, noble metal nanorods and nanoshells have come to the fore to potentially revolutionize the biomedical field. These nanotechnology constructs may indeed overcome the limitation of conventional diagnostic systems and offer promising alternatives to conventional therapeutic agents. Their small size and subsequent high surface-to-volume ratio translates into unique physical properties such as superparamagnetism, high yield and photostable luminescence, or shape and size-tuneable optical properties. There is not to date a unanimously accepted definition of what is a nanoparticle; this review will, however, consider a nanoparticle as a nanometer-sized solid structure inheriting unique physico-chemical properties, different from those of the bulk materials, from their small dimension. In the case of magnetite nanoparticles, this usually occurs for nanoparticles less than 30 nm in diameter, which exhibit super paramagnetism at room temperature, a property related to the large magnetic moment resulting from the coupling of the atomic spins within the nano-sized magnetite nanoparticles. Small single-domain super paramagnetic magnetite nanoparticles are often referred as SPIONs (superparamagnetic iron oxide nanoparticles) or USPIONs (ultrasmall superparamagnetic iron oxide nanoparticles) depending on their hydrodynamic diameter. Several magnetic nanoparticles are currently commercially available or under advanced clinical investigations, for instance, Ferimoxides (Endorem/Feridex) and Ferumoxtran-10 from Guerbet Advanced Magnetics.
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Copyright 2009 Taylor and Francis Group