VEGF Receptor Signalling in Vertebrate Development

Date

2008

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Vieira, J.
Ruhrberg, C.
Schwarz, Q.P.

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Source details - Title: VEGF in Development, 2008, Ch.2, pp.14-29

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Abstract

The secreted glycoprotein vascular endothelial growth factor A (VEGF or VEGFA) affects many different cell types and modifies a wide spectrum of cellular behaviours in tissue culture models, including proliferation, migration, differentiation and survival. The versatility of VEGF signalling is reflected in the complex composition of its cell surface receptors and their ability to activate a variety of different downstream signalling molecules. A major challenge for VEGF research is to determine which of the specific signalling pathways identified in vitro.

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Copyright 2008 Springer

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