A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead

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dc.contributor.authorWilanowski, T.
dc.contributor.authorTuckfield, A.
dc.contributor.authorCerruti, L.
dc.contributor.authorO'Connell, S.
dc.contributor.authorSaint, R.
dc.contributor.authorParekh, V.
dc.contributor.authorTao, J.
dc.contributor.authorCunningham, J.
dc.contributor.authorJane, S.
dc.contributor.organisationCentre for the Molecular Genetics of Development
dc.date.issued2002
dc.description.abstractThe Drosophila transcription factor Grainyhead regulates several key developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been previously identified as homologues of grainyhead. We now report the cloning of two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence homology with grh, is expressed in tissue-restricted patterns more comparable to grh and binds to and transactivates the promoter of the human Engrailed-1 gene, the mammalian homologue of the key grainyhead target gene, engrailed. This sequence and functional conservation indicates that the new mammalian members of this family play important developmental roles.
dc.description.urihttp://www.sciencedirect.com/science/journal/09254773
dc.identifier.citationMechanisms of Development, 2002; 114(1-2):37-50
dc.identifier.doi10.1016/S0925-4773(02)00046-1
dc.identifier.issn0925-4773
dc.identifier.issn1872-6356
dc.identifier.urihttp://hdl.handle.net/2440/28129
dc.language.isoen
dc.publisherElsevier Science BV
dc.source.urihttps://doi.org/10.1016/s0925-4773(02)00046-1
dc.subjectGrainyhead
dc.subjectHomologue
dc.titleA highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead
dc.typeJournal article
pubs.publication-statusPublished

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