Glycine receptor α2 subunit activation promotes cortical interneuron migration
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Date
2013
Authors
Avila, A.
Vidal, P.
Dear, T.
Harvey, R.
Rigo, J.
Nguyen, L.
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Cell reports, 2013; 4(4):738-750
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Ariel Avila, Pía M. Vidal, T. Neil Dear, Robert J. Harvey, Jean-Michel Rigo, Laurent Nguyen
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Abstract
Glycine receptors (GlyRs) are detected in the developing CNS before synaptogenesis, but their function remains elusive. This study demonstrates that functional GlyRs are expressed by embryonic cortical interneurons in vivo. Furthermore, genetic disruption of these receptors leads to interneuron migration defects. We discovered that extrasynaptic activation of GlyRs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. Taken together, our data highlight the molecular events triggered by GlyR α2 activation that control cortical tangential migration during embryogenesis.
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Copyright © 2013 The Authors; This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.