Impairment of uterine contractility is associated with unexplained infertility

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dc.contributor.authorHunt, S.
dc.contributor.authorAbdallah, K.S.
dc.contributor.authorNg, E.
dc.contributor.authorRombauts, L.
dc.contributor.authorVollenhoven, B.
dc.contributor.authorMol, B.W.
dc.date.issued2020
dc.description.abstractThe uterine junctional zone represents the juncture between endometrium and myometrium. The junctional zone is hormonally dependent and displays continuous peristaltic activity throughout the menstrual cycle in the nonpregnant state which is concerned with sperm transport and embryo implantation. Peristalsis may be observed using various invasive and noninvasive modalities, of which ultrasound is the most readily applied in the clinical setting. Women with pelvic pathology display alterations in uterine peristalsis which may contribute to infertility. Characterization of peristalsis in infertility subgroups, the development of a subjective peristalsis tool, and the application of potential therapeutics to an assisted reproductive treatment setting are the subject of ongoing investigation. Meta-analysis indicates a potential role for oxytocin antagonist in the improvement of fertility treatments.
dc.description.statementofresponsibilitySarah Hunt, Karim S. Abdallah, Ernest Ng, Luk Rombauts, Beverley Vollenhoven, Ben W. Mol
dc.identifier.citationSeminars in Reproductive Medicine, 2020; 38(1):61-73
dc.identifier.doi10.1055/s-0040-1716409
dc.identifier.issn1526-8004
dc.identifier.issn1526-4564
dc.identifier.orcidMol, B.W. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.urihttp://hdl.handle.net/2440/129689
dc.language.isoen
dc.publisherThieme Medical Publishers
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1176437
dc.rightsCopyright © 2020 by Thieme Medical Publishers, Inc.
dc.source.urihttps://doi.org/10.1055/s-0040-1716409
dc.subjectEndometrial myometrial junction; uterine junctional zone; endometrial contractions; uterine peristalsis
dc.titleImpairment of uterine contractility is associated with unexplained infertility
dc.typeJournal article
pubs.publication-statusPublished

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