Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort
Date
2011
Authors
Beckmann, K.R.
Buckingham, J.
Craft, P.
Dahlstrom, J.E.
Zhang, Y.
Roder, D.
Stuart Harris, R.
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Journal article
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Breast, 2011; 20(2):158-164
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Abstract
Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort.Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors.Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21–4.21].Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.
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Copyright 2010 Elsevier under a Creative Commons license (https://creativecommons.org/licenses/by-nc-nd/4.0/)