Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation
Date
2011
Authors
Byrne, J.
Morona, J.
Paton, J.
Morona, R.
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Journal article
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Journal of Bacteriology, 2011; 193(9):2341-2346
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James P. Byrne, Judy K. Morona, James C. Paton, and Renato Morona
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Abstract
A number of single amino acid substitutions throughout Streptococcus pneumoniae Cps2C were found to affect its function and confer either a mucoid or a small colony phenotype. These mutants exhibit significant changes in capsular polysaccharide (CPS) profile relative to that of wild-type pneumococci. The introduced mutations affect either polymerization or ligation of CPS to the cell wall and/or Cps2D phosphorylation.
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Copyright © 2011, American Society for Microbiology. All Rights Reserved.