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The role of stem cell mobilization regimen on lymphocyte collection yield in patients with multiple myeloma

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dc.contributor.authorHiwase, D.
dc.contributor.authorHiwase, S.
dc.contributor.authorBailey, M.
dc.contributor.authorBollard, G.
dc.contributor.authorSchwarer, A.
dc.date.issued2008
dc.description.abstractBackground The lymphocyte dose (LY-DO) infused during an autograft influences absolute lymphocyte (ALC) recovery and survival following autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients. Factors influencing lymphocyte yield (LY-C) during leukapheresis have been poorly studied. Methods Factors that could influence survival, LY-C and CD34+ cell yield were analyzed in 122 MM patients. Three mobilization regimens were used, granulocyte-colony-stimulating factor (G-CSF) alone (n=13), cyclophosphamide 1-2 g/m2 plus G-CSF (LD-CY, n=62) and cyclophosphamide 3-4 g/m2 and G-CSF (ID-CY, n=47). Results Using multivariate analysis, age, LY-C, ALC on day 30 (ALC-30) and International Staging System stage significantly influenced overall (OS) and progression-free survival (PFS) following ASCT. PFS (56 versus 29 months, P=0.05) and OS (72 versus 49 months; P=0.07) were longer in the LY-C≥0.12109/kg group than the LY-C<0.12109/kg group. LY-C also influenced ALC on day 15 (ALC-15). Mobilization regimen, lymphocytes on the day of leukapheresis, prior radiotherapy and number of leukaphereses significantly influenced LY-C. Significantly higher LY-C was obtained with G-CSF alone compared with the LD-CY and ID-CY groups. CD34+ count on the day of leukapheresis, prior chemotherapy with prednisone, cyclophosphamide, adriamycin and BCNU or melphalan, and stem cell mobilization regimen significantly influenced CD34+ cell yield. Discussion LY-C influenced ALC-15 and survival following ASCT. Factors that influenced CD34+ cell yield and LY-C during leukapheresis were different. Mobilization should be tailored to maximize the LY-C and CD34+ cell yield.
dc.description.statementofresponsibilityD.K. Hiwase, S. Hiwase, M. Bailey, G. Bollard and A.P. Schwarer
dc.identifier.citationCytotherapy, 2008; 10(5):507-517
dc.identifier.doi10.1080/14653240802165665
dc.identifier.issn1465-3249
dc.identifier.issn1477-2566
dc.identifier.orcidHiwase, D. [0000-0002-6666-3056]
dc.identifier.urihttp://hdl.handle.net/2440/51905
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.source.urihttps://doi.org/10.1080/14653240802165665
dc.subjectautologous stem cell transplantation
dc.subjectlymphocyte collection
dc.subjectmultiple myeloma
dc.titleThe role of stem cell mobilization regimen on lymphocyte collection yield in patients with multiple myeloma
dc.typeJournal article
pubs.publication-statusPublished

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