Risks of colorectal and other cancers after endometrial cancer for women with lynch syndrome

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dc.contributor.authorWin, A.
dc.contributor.authorLindor, N.
dc.contributor.authorWinship, I.
dc.contributor.authorTucker, K.
dc.contributor.authorBuchanan, D.
dc.contributor.authorYoung, J.
dc.contributor.authorRosty, C.
dc.contributor.authorLeggett, B.
dc.contributor.authorGiles, G.
dc.contributor.authorGoldblatt, J.
dc.contributor.authorMacrae, F.
dc.contributor.authorParry, S.
dc.contributor.authorKalady, M.
dc.contributor.authorBaron, J.
dc.contributor.authorAhnen, D.
dc.contributor.authorMarchand, L.
dc.contributor.authorGallinger, S.
dc.contributor.authorHaile, R.
dc.contributor.authorNewcomb, P.
dc.contributor.authorHopper, J.
dc.contributor.authoret al.
dc.date.issued2013
dc.description.abstractBACKGROUND: Lynch syndrome is an autosomal dominantly inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Previous studies have shown that MMR gene mutation carriers are at increased risk of colorectal, endometrial, and several other cancers following an initial diagnosis of colorectal cancer. We estimated cancer risks following an endometrial cancer diagnosis for women carrying MMR gene mutations. METHODS: We obtained data from the Colon Cancer Family Registry for a cohort of 127 women who had a diagnosis of endometrial cancer and who carried a mutation in one of four MMR genes (30 carried a mutation in MLH1, 72 in MSH2, 22 in MSH6, and 3 in PMS2). We used the Kaplan-Meier method to estimate 10- and 20-year cumulative risks for each cancer. We estimated the age-, country-, and calendar period-specific standardized incidence ratios (SIRs) for each cancer, compared with the general population. RESULTS: Following endometrial cancer, women carrying MMR gene mutations had the following 20-year risks of other cancer cancers: colorectal cancer (48%, 95% confidence interval [CI] = 35% to 62%); cancer of the kidney, renal pelvis, or ureter (11%, 95% CI = 3% to 20%); urinary bladder cancer (9%, 95% CI = 2% to 17%); and breast cancer (11%, 95% CI = 4% to 19%). Compared with the general population, these women were at statistically significantly elevated risks of colorectal cancer (SIR = 39.9, 95% CI = 27.2 to 58.3), cancer of the kidney, renal pelvis, or ureter (SIR = 28.3, 95% CI = 11.9 to 48.6), urinary bladder cancer (SIR = 24.3, 95% CI = 8.56 to 42.9), and breast cancer (SIR = 2.51, 95% CI = 1.17 to 4.14). CONCLUSIONS: Women with Lynch syndrome who are diagnosed with endometrial cancer have increased risks of several cancers, including breast cancer.
dc.description.statementofresponsibilityAung Ko Win, Noralane M. Lindor, Ingrid Winship, Katherine M. Tucker, Daniel D. Buchanan, Joanne P. Young, Christophe Rosty, Barbara Leggett, Graham G. Giles, Jack Goldblatt, Finlay A. Macrae, Susan Parry, Matthew F. Kalady, John A. Baron, Dennis J. Ahnen, Loic Le Marchand, Steven Gallinger, Robert W. Haile, Polly A. Newcomb, John L. Hopper and Mark A. Jenkins​
dc.identifier.citationJournal of the National Cancer Institute, 2013; 105(4):274-279
dc.identifier.doi10.1093/jnci/djs525
dc.identifier.issn0027-8874
dc.identifier.issn1460-2105
dc.identifier.orcidYoung, J. [0000-0002-1514-1522]
dc.identifier.urihttp://hdl.handle.net/2440/92310
dc.language.isoen
dc.publisherOxford University Press
dc.rights© The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com
dc.source.urihttps://doi.org/10.1093/jnci/djs525
dc.subjectBreast Neoplasms
dc.subjectColorectal Neoplasms
dc.subjectColorectal Neoplasms, Hereditary Nonpolyposis
dc.subjectEndometrial Neoplasms
dc.subjectUrologic Neoplasms
dc.subjectAdaptor Proteins, Signal Transducing
dc.subjectDNA-Binding Proteins
dc.subjectNuclear Proteins
dc.subjectGerm-Line Mutation
dc.subjectAdenosine Triphosphatases
dc.subjectMutS Homolog 2 Protein
dc.subjectDNA Repair Enzymes
dc.subjectNeoplasms
dc.subjectKaplan-Meier Estimate
dc.subjectDNA Mismatch Repair
dc.subjectSkin Neoplasms
dc.subjectHeterozygote
dc.titleRisks of colorectal and other cancers after endometrial cancer for women with lynch syndrome
dc.typeJournal article
pubs.publication-statusPublished

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