Delivering a cell therapy
Date
2015
Authors
Kirby, G.
Vandenpoel, L.
Pinxteren, J.
Short, R.
Michelmore, A.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Cytotherapy, 2015; 17(6):14-
Statement of Responsibility
Conference Name
Abstract
Background, Chronic wounds are a growing clinical burden on healthcare systems and with increasing incidences of obesity, diabetes and an aging population this problem is set to snowball. Chronic wounds present a hostile environment and unique challenges. Cell therapies may offer a solution with a range of cell based approaches beginning to cross the rift from bench-to-bedside. Supporting data suggests that the appropriate administration of stem cells can accelerate wound healing. The effectiveness of a therapy will depend not only on what we deliver but how we deliver it.
Aims or Objectives, Our aim was to generate a method of delivering cells to wounds where injection may not be ideal. We achieved this by manufacturing a cell-laden bandage. This bandage was capable of supporting cell attachment without affecting phenotype. When placed onto a wound, the cells then leave this surface in preference for the wound
Materials and Methods, Plasma polymerisation was used to generate a range of functional surfaces on candidate dressings. Coating conditions were varied and these surfaces were then tested with multipotent adult progenitor cells (MAPC). An in vitro transfer assay was used to determine the migration of viable cells from the patch onto a wound model.
Results & Discussion, By varying surface treatments we were able to optimise a range of surfaces that supported the attachment of MAPC and subsequently allow these cells to leave in preference for a model wound bed.
Conclusions, There is mounting evidence showing that cell therapies are effective in the treatment of chronic wounds. In order to promote clinical uptake of these new approaches, we need to make the use and delivery of cell therapies simple and effective. Our approach aims to create a simple bandage that is non-traumatic and easily applied at the bedside
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2015 Published by Elsevier