Pilidiostigmin, a novel bioactive dimeric acylphloroglucinol derivative isolated from Pilidiostigma glabrum
Date
2013
Authors
Shou, Q.
Sun, H.
Banbury, L.K.
Lambley, E.H.
Renshaw, D.E.
Griesinger, C.
Griesser, H.J.
Wohlmuth, H.
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Journal article
Citation
Tetrahedron Letters, 2013; 54(14):1853-1856
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Abstract
Pilidiostigmin, a novel dimeric acylphloroglucinol derivative, was isolated from the leaves of the Australian plant species Pilidiostigma glabrum (Myrtaceae). Pilidiostigmin exists in the plant in the form of a sodium salt, which is rare in natural products. The elucidation of the structure and relative configuration was achieved by spectroscopic measurements with special emphasis on 1D and 2D NMR techniques. Pilidiostigmin was found to display biological activity; it significantly and dose-dependently inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages at low micromolar concentrations.
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Link to a related website: http://hdl.handle.net/11858/00-001M-0000-000E-F5C2-4, Open Access via Unpaywall
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Copyright 2013 Elsevier