Physiologically based pharmacokinetics and pharmacodynamics of skin
Date
2008
Authors
Dancik, Y.
Jepps, O.
Roberts, M.S.
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Book chapter
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Source details - Title: Dermal absorption and toxicity assessment, 2008, pp.179-207
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Abstract
The study of the percutaneous absorption and penetration of exogenous compounds through human skin is relevant to transdermal drug delivery and risk assessment of toxic chemicals. Around 40% of drugs under clinical evaluation are related to delivery to or through the skin (1). The transdermal mode of delivery offers the possibility of eliminating the pain and possible infection associated with injections. It also enables the drug to bypass the hepatic first pass associated with oral delivery, and can provide sustained release of the drug for up to seven days (2). An earlier review of transdermal delivery was provided by Roberts et al. (3).
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