Studies toward the total synthesis of the variolins: rapid entry to the core structure
Date
2001
Authors
Anderson, Regan James
Morris, Jonathan Charles
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Tetrahedron Letters, 2001; 42(2):311-313
Statement of Responsibility
Regan J. Anderson and Jonathan C. Morris
Conference Name
Abstract
The pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine core structure of the variolins has been synthesized in three steps from commercially available materials. The key reaction involves the deoxygenation and concomitant cyclization of a triarylmethanol using the combination of triethylsilane and trifluoroacetic acid. Introduction of amine functionality as required for the natural products has been achieved in two steps.
School/Discipline
School of Chemistry and Physics : Chemistry