The function of the Drosophila caspase DRONC in cell death and development

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dc.contributor.authorMills, K.
dc.contributor.authorDaish, T.
dc.contributor.authorKumar, S.
dc.date.issued2005
dc.description.abstractdronc, the only apical caspase in Drosophila is thought to be essential and non-redundant for apoptosis. Recent analyses of several independently derived dronc mutants have demonstrated that DRONC is required for normal development. Interestingly, analysis of these mutants show that DRONC is not essential for cell death in all tissues and that in some cases, DRONC-independent effector caspase activation and apoptosis can occur. These mutants provide a valuable resource to investigate the recently reported roles of DRONC in non-apoptotic pathways. Insights gained from the dronc mutants will help in advancing our understanding of caspase function in various developmental pathways.
dc.description.statementofresponsibilityKathryn Mills, Tasman Daish and Sharad Kumar
dc.identifier.citationCell Cycle, 2005; 4(6):744-746
dc.identifier.doi10.4161/cc.4.6.1740
dc.identifier.issn1538-4101
dc.identifier.issn1551-4005
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]
dc.identifier.urihttp://hdl.handle.net/2440/38876
dc.language.isoen
dc.publisherLandes Bioscience
dc.source.urihttps://doi.org/10.4161/cc.4.6.1740
dc.subjectAnimals
dc.subjectDrosophila
dc.subjectCaspases
dc.subjectDrosophila Proteins
dc.subjectCell Death
dc.subjectModels, Biological
dc.titleThe function of the Drosophila caspase DRONC in cell death and development
dc.typeJournal article
pubs.publication-statusPublished

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