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Life-course socioeconomic position and incidence of coronary heart disease: the Framingham Offspring Study

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dc.contributor.authorLoucks, E.
dc.contributor.authorLynch, J.
dc.contributor.authorPolite, L.
dc.contributor.authorFuhrer, R.
dc.contributor.authorAlmeida, N.
dc.contributor.authorRichard, H.
dc.contributor.authorAgha, G.
dc.contributor.authorMurabito, J.
dc.contributor.authorBenjamin, E.
dc.date.issued2009
dc.descriptionData source: Supplementary data, https://doi.org/10.1093/aje/kwn403
dc.description.abstractCumulative exposure to socioeconomic disadvantage across the life course may be inversely associated with coronary heart disease (CHD); the mechanisms are not fully clear. An objective of this study was to determine whether cumulative life-course socioeconomic position (SEP) is associated with CHD incidence in a well-characterized US cohort that had directly assessed childhood and adulthood measures of SEP and prospectively measured CHD incidence. Furthermore, analyses aimed to evaluate whether adjustment for CHD risk factors reduces the association between cumulative life-course SEP and CHD. The authors examined 1,835 subjects who participated in the Framingham Heart Study Offspring Cohort from 1971 through 2003 (mean age, 35.0 years; 52.4% women). Childhood SEP was measured as father's education; adulthood SEP was assessed as own education and occupation. CHD incidence included myocardial infarction, coronary insufficiency, and coronary death. Cox proportional hazards analyses indicated that cumulative SEP was associated with incident CHD after adjustment for age and sex (hazard ratio = 1.82, 95% confidence interval: 1.17, 2.85 for low vs. high cumulative SEP score). Adjustment for CHD risk factors reduced that magnitude of association (hazard ratio = 1.29, 95% confidence interval: 0.78, 2.13). These findings underscore the potential importance of CHD prevention and treatment efforts for those whose backgrounds include low SEP throughout life.
dc.description.statementofresponsibilityEric B. Loucks, John W. Lynch, Louise Pilote, Rebecca Fuhrer, Nisha D. Almeida, Hugues Richard, Golareh Agha, Joanne M. Murabito, and Emelia J. Benjamin
dc.identifier.citationAmerican Journal of Epidemiology, 2009; 169(7):829-836
dc.identifier.doi10.1093/aje/kwn403
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256
dc.identifier.orcidLynch, J. [0000-0003-2781-7902]
dc.identifier.urihttp://hdl.handle.net/2440/65655
dc.language.isoen
dc.publisherOxford Univ Press
dc.rights© The Author 2009.
dc.source.urihttps://doi.org/10.1093/aje/kwn403
dc.subjectcohort studies
dc.subjectcoronary disease
dc.subjectmyocardial ischemia
dc.subjectsocial class
dc.subjectsocioeconomic factors
dc.titleLife-course socioeconomic position and incidence of coronary heart disease: the Framingham Offspring Study
dc.typeJournal article
pubs.publication-statusPublished

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