Characterising the contribution of auditory and somatosensory inputs to TMS-evoked potentials following stimulation of prefrontal, premotor, and parietal cortex

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dc.contributor.authorBiabani, M.
dc.contributor.authorFornito, A.
dc.contributor.authorGoldsworthy, M.
dc.contributor.authorThompson, S.
dc.contributor.authorGraetz, L.
dc.contributor.authorSemmler, J.G.
dc.contributor.authorOpie, G.M.
dc.contributor.authorBellgrove, M.A.
dc.contributor.authorRogasch, N.C.
dc.date.issued2024
dc.description.abstractTranscranial magnetic stimulation (TMS) results in a series of deflections in electroencephalography (EEG) recordings known as a TMS-evoked potential (TEP). However, it remains unclear whether these responses reflect neural activity resulting from transcranial stimulation of the cortex, the sensory experiences of TMS, or a combination of the two. Across three experiments (total n = 135), we recorded EEG activity following TMS to the dorsolateral prefrontal cortex, premotor cortex, and parietal cortex as well as a sensory control condition (stimulation of the shoulder or electrical stimulation of the scalp with a click sound). We found that TEPs showed a stereotypical frontocentral N100/P200 complex following TMS of all cortical sites and control conditions, regardless of TMS intensity or the type of sensory control. In contrast, earlier TEPs (<60 ms) showed site-specific characteristics which were largest at the site of stimulation, although TEP topographies were distorted in a subgroup of individuals due to residual TMS-evoked muscle artefact despite cleaning with independent component analysis. Self-reported sensory experiences differed across sites, with prefrontal stimulation resulting in stronger auditory (click sound perception) and somatosensory input (scalp muscle twitch, discomfort) than premotor or parietal stimulation, a pattern that was reflected in the amplitude of later (N100/P200), but not earlier (<60 ms), TEP peak amplitudes. Later TEPs were also larger in individuals who experienced stronger click sound perception and, to a lesser extent, TMS-evoked scalp muscle twitches. Increasing click sound perception by removing auditory masking increased N100/P200 amplitudes without altering earlier peaks, an effect which was more prominent at sites with more successful masking. Together, these findings suggest that the frontocentral N100/P200 complex primarily represents a generalised sensory response resulting from TMS-related auditory and somatosensory input when present. In contrast, early TEP peaks likely primarily reflect activity resulting from transcranial stimulation of the cortex when artefacts were adequately accounted for. The results have important implications for designing and interpreting TEP studies, especially when comparing TEPs between stimulation sites and participant groups showing differences in sensory experiences following TMS.
dc.description.statementofresponsibilityMana Biabani, Alex Fornito, Mitchell Goldsworthy, Sarah Thompson, Lynton Graetz, John G. Semmler, George M. Opie, Mark A. Bellgrove, Nigel C. Rogasch
dc.identifier.citationImaging Neuroscience, 2024; 2(2024):1-23
dc.identifier.doi10.1162/imag_a_00349
dc.identifier.issn2837-6056
dc.identifier.issn2837-6056
dc.identifier.orcidGoldsworthy, M. [0000-0002-0688-9475]
dc.identifier.orcidGraetz, L. [0000-0001-9163-3150]
dc.identifier.orcidSemmler, J.G. [0000-0003-0260-8047]
dc.identifier.orcidOpie, G.M. [0000-0001-7771-7569]
dc.identifier.orcidRogasch, N.C. [0000-0002-4484-1069]
dc.identifier.urihttps://hdl.handle.net/2440/147971
dc.language.isoen
dc.publisherThe MIT Press
dc.relation.granthttp://purl.org/au-research/grants/arc/DP170100738
dc.relation.granthttp://purl.org/au-research/grants/arc/DE180100741
dc.relation.granthttp://purl.org/au-research/grants/arc/FT210100694
dc.rights© 2024 The Authors. Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license.
dc.source.urihttps://doi.org/10.1162/imag_a_00349
dc.subjecttranscranial magnetic stimulation; electroencephalography; TMS-evoked potentials; sensory; auditory; somatosensory; muscle; dorsolateral prefrontal cortex; premotor cortex; parietal cortex
dc.titleCharacterising the contribution of auditory and somatosensory inputs to TMS-evoked potentials following stimulation of prefrontal, premotor, and parietal cortex
dc.typeJournal article
pubs.publication-statusPublished

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