HTR2A gene variation is involved in antidepressant treatment response

Date

2010

Authors

Lucae, S.
Ising, M.
Horstmann, S.
Baune, B.
Arolt, V.
Muller-Myhsok, B.
Holsboer, F.
Domschke, K.

Editors

Advisors

Journal Title

Journal ISSN

Volume Title

Type:

Journal article

Citation

European Neuropsychopharmacology, 2010; 20(1):65-68

Statement of Responsibility

Susanne Lucae, Marcus Ising, Sonja Horstmann, Bernhard T. Baune, Volker Arolt, Bertram Müller-Myhsok, Florian Holsboer, Katharina Domschke

Conference Name

DOI

10.1016/j.euroneuro.2009.08.006

Abstract

Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.

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Dissertation Note

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© 2009 Elsevier B.V. and ECNP All rights reserved.

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Published Version

https://doi.org/10.1016/j.euroneuro.2009.08.006

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Persistent link to this record

http://hdl.handle.net/2440/65744