Mining heterogeneous causal effects for personalized cancer treatment
Date
2017
Authors
Zhang, W.
Le, T.D.
Liu, L.
Zhou, Z.H.
Li, J.
Editors
Wren, J.
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Bioinformatics, 2017; 33(15):2372-2378
Statement of Responsibility
Conference Name
Abstract
<h4>Motivation</h4>Cancer is not a single disease and involves different subtypes characterized by different sets of molecules. Patients with different subtypes of cancer often react heterogeneously towards the same treatment. Currently, clinical diagnoses rather than molecular profiles are used to determine the most suitable treatment. A molecular level approach will allow a more precise and informed way for making treatment decisions, leading to a better survival chance and less suffering of patients. Although many computational methods have been proposed to identify cancer subtypes at molecular level, to the best of our knowledge none of them are designed to discover subtypes with heterogeneous treatment responses.<h4>Results</h4>In this article we propose the Survival Causal Tree (SCT) method. SCT is designed to discover patient subgroups with heterogeneous treatment effects from censored observational data. Results on TCGA breast invasive carcinoma and glioma datasets have shown that for each subtype identified by SCT, the patients treated with radiotherapy exhibit significantly different relapse free survival pattern when compared to patients without the treatment. With the capability to identify cancer subtypes with heterogeneous treatment responses, SCT is useful in helping to choose the most suitable treatment for individual patients.<h4>Availability and implementation</h4>Data and code are available at https://github.com/WeijiaZhang24/SurvivalCausalTree .<h4>Contact</h4>weijia.zhang@mymail.uinsa.edu.au.<h4>Supplementary information</h4>Supplementary data are available at Bioinformatics online.
School/Discipline
Dissertation Note
Provenance
Description
Data source: Data and code available, https://github.com/WeijiaZhang24/SurvivalCausalTree
Access Status
Rights
Copyright 2017 The Authors. Published by Oxford University Press.
Access Condition Notes: This article is freely available from the publisher