Engineered Silica Nanoparticles for Nucleic Acid Delivery
Date
2024
Authors
Zhang, Y.
Yu, Y.
Yang, Y.
Wang, Y.
Yu, C.
Editors
Advisors
Journal Title
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Volume Title
Type:
Journal article
Citation
Small Methods, 2024; 8(3):2300812-1-2300812-16
Statement of Responsibility
Yue Zhang, Yingjie Yu, Yannan Yang, Yue Wang, and Chengzhong Yu
Conference Name
Abstract
The development of nucleic acid‐based drugs holds great promise for therapeutic applications, but their effective delivery into cells is hindered by poor cellular membrane permeability and inherent instability. To overcome these challenges, delivery vehicles are required to protect and deliver nucleic acids efficiently. Silica nanoparticles (SiNPs) have emerged as promising nanovectors and recently bioregulators for gene delivery due to their unique advantages. In this review, a summary of recent advancements in the design of SiNPs for nucleic acid delivery and their applications is provided, mainly according to the specific type of nucleic acids. First, the structural characteristics and working mechanisms of various types of nucleic acids are introduced and classified according to their functions. Subsequently, for each nucleic acid type, the use of SiNPs for enhancing delivery performance and their biomedical applications are summarized. The tailored design of SiNPs for selected type of nucleic acid delivery will be highlighted considering the characteristics of nucleic acids. Lastly, the limitations in current research and personal perspectives on future directions in this field are presented. It is expected this opportune review will provide insights into a burgeoning research area for the development of next‐generation SiNP‐based nucleic acid delivery systems.
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Dissertation Note
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Description
Published online: October 31, 2023
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© 2023 Wiley-VCH GmbH