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Metal organic frameworks as a drug delivery system for flurbiprofen

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dc.contributor.authorAL Haydar, M.
dc.contributor.authorAbid, H.R.
dc.contributor.authorSunderland, B.
dc.contributor.authorWang, S.
dc.date.issued2017
dc.description.abstractBackground: Metal organic frameworks (MOFs) have attracted more attention in the last decade because of a suitable pore size, large surface area, and high pore volume. Developing biocompatible MOFs such as the MIL family as a drug delivery system is possible. Purpose: Flurbiprofen (FBP), a nonsteroidal anti-inflammatory agent, is practically insoluble in aqueous solution, and, therefore, needs suitable drug delivery systems. Different biocompatible MOFs such as Ca-MOF and Fe-MILs (53, 100, and 101) were synthesized and employed for FBP delivery. Patients and Methods: A sample of 50 mg of each MOF was mixed and stirred for 24 h with 10 mL of 5 mg FBP in acetonitrile (40%) in a sealed container. The supernatant of the mixture after centrifuging was analyzed by high-performance liquid chromatography to determine the loaded quantity of FBP on the MOF. The overnight-dried solid material after centrifuging the mixture was analyzed for loading percent using X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, nuclear magnetic resonance, and FBP release profile. Results: The loading values of FBP were achieved at 10.0%±1%, 20%±0.8%, 37%±2.3%, and 46%±3.1% on Ca-MOF, Fe-MIL-53, Fe-MIL-101, and Fe-MIL-100, respectively. The FBP release profiles were investigated in a phosphate buffer solution at pH 7.4. The total release of the FBP after 2 days was obtained at 72.9, 75.2, 78.3, and 90.3% for Ca-MOF, Fe-MIL-100, Fe-MIL-53, and Fe-MIL-101, respectively. Conclusion: The MOFs are shown to be a promising drug delivery option for FBP with a significant loading percent and relatively prolonged drug release.
dc.description.statementofresponsibilityMuder AL Haydar, Hussein Rasool Abid, Bruce Sunderland, Shaobin Wang
dc.identifier.citationDrug Design, Development and Therapy, 2017; 11:2685-2695
dc.identifier.doi10.2147/DDDT.S145716
dc.identifier.issn1177-8881
dc.identifier.issn1177-8881
dc.identifier.orcidWang, S. [0000-0002-1751-9162]
dc.identifier.urihttp://hdl.handle.net/2440/119200
dc.language.isoen
dc.publisherDove Medical Press
dc.rights© 2017 AL Haydar et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
dc.source.urihttps://doi.org/10.2147/dddt.s145716
dc.subjectPorous MOF; FBP; drug loading; drug release
dc.titleMetal organic frameworks as a drug delivery system for flurbiprofen
dc.typeJournal article
pubs.publication-statusPublished

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